Differentiation of Chicken Embryonic Stem cells (CESc) toward the ectodermic lineage: at day 30 post plating in differentiating conditions cell monolayers are stained with antibodies to cytokeratin (red) and occludin (green), thus enabling the visualization of a cuboidal epithelium, typical for chicken keratinocytes in culture. © INRAE, Vautherot J-F, Couteaudier M
Infectious Diseases and Public Health
Research
Virology teams
Biology of Avian Viruses

Biology of Avian Viruses

Team leader: Caroline Denesvre

Differentiation of Chicken Embryonic Stem cells (CESc) toward the ectodermic lineage: at day 30 post plating in differentiating conditions cell monolayers are stained with antibodies to cytokeratin (red) and occludin (green), thus enabling the visualization of a cuboidal epithelium, typical for chicken keratinocytes in culture. © INRAE, Vautherot J-F, Couteaudier M

Research

Marek's disease  virus (MDV) is a highly contagious virus of chicken that causes a world widespread and economically important production disease. MDV induces transient immunosuppression and fatal T-cell lymphoma. Current vaccines protect well against tumor formation but not against infection and viral shedding. This explains the persistence of the virus and its possible evolution towards increased virulence. 
We focus our research on the relationships between MDV and its host. Our main research themes aim to:
> identify cellular and viral determinants involved in the persistence of MDV in feathers, in virus excretion into environment and transmission between birds;
> characterize the role of hypoxia in the life cycle of MDV and MDV-induced lymphomagenesis;
> improve the prevention of Marek's disease and vaccine platforms derived from Mardiviruses to better fight against avian pathogens and preserve the environment;
> screen anti-MDV chemical molecules in vitro;
> develop new in vitro avian skin models to study virus/skin interactions, in order to reduce animal experiments.

Publications

Pubmed since 2012

Team

Scientific staff:
Denesvre Caroline
Pasdeloup David
Souci Laurent
Trapp-Fragnet Laëtitia

Technicians:
Chollot Mélanie
Guyader Katia

PhD student :
Durand Mallorie

Modification date: 07 February 2024 | Publication date: 08 March 2017 | By: "Biology of Avian Viruses" team