Microbiota, Monogastric and Salmonella

Research

Depending of the hosts and the serotypes, Salmonella induce a wide spectrum of diseases among which gastro-enteritis, typhoid fever and asymptomatic infections.
Within the host, Salmonella is able to infect a large array of cells, leading to the paradigm that cell invasion is a key step in Salmonella pathogenesis. The role of this step in Salmonella pathogenesis has been neglected due to the belief that Salmonella  has only one entry pathway: the T3SS-1. However, at least two other entry factors were identified recently.
We focus our research on the:
> mechanisms of Salmonella carrier state in chicken by comparison to Salmonella virulence in susceptible mice;
> impact of intestinal microbiota on transmission and host infection;
> role of the different cell invasion pathways in the pathogenesis of Salmonella.
We use complementary approaches:
> characterization and regulation of bacterial factors involved in Salmonella-cell interactions in relation to virulence and asymptomatic carrier state ;
> identification and characterization of the T3SS-1 independent cell entry mechanisms mediated by Salmonella and the behaviours following these entries ;
> in vivo mechanisms involved in resistance to carrier state and transmission between chicks.

Publications

Pubmed since 2012

Team

Scientific staff:
Grépinet Olivier
Holbert Sébastien
Kapetanovic Ronan
Kempf Florent
Lalmanach Anne-Christine
Schouler Catherine
Trotereau Jérôme
Velge Philippe
Virlogeux-Payant Isabelle

Technician and assistant engineer:
Barilleau Emilie
Kopp Lisa

PhD students :
Boucard Etienne
Devallière Coline
Lopatynski Cassandra